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January 11, 2016 at 07:54 AM
(Bloomberg) — A billionaire entrepreneur has pulled together a coalition of drugmakers to speed development of what researchers believe could be a powerful weapon against cancers — potent combinations of new drugs that harness the body’s immune system.
So-called immunotherapies help disease-fighting cells attack tumors. Yet researchers believe they may work best when two, three or more of the drugs are used together — overwhelming a tumor’s cellular defenses with attacks from all sides.
The group brought together by Patrick Soon-Shiong calls itself Moonshot 2020 and also includes academic institutions and insurers. Its leaders hope to get competing drug and biotech companies to work together on the combination treatments rather than developing their own compounds in isolation.
“The key contribution here is the ability to run combination studies with drugs from multiple pharma companies in a rapid manner,” said Manuel Hidalgo, clinical director of the Cancer Center at Beth Israel Deaconess Medical Center in Boston. “Combination studies with unapproved drugs from different pharma companies are not easy to do, and we want to be able combine three to four drugs, not just two.”
While the immunotherapies have side effects of their own, physicians have hoped they can be better tailored to a patient’s tumor profile, and someday replace or supplement chemotherapy, which is thought of as a blunt tool with high toxicity.
See also: The gene-editing tool on every drugmaker’s wish list this year
The group aims to complete clinical trials for up to 20 tumor types in as many as 20,000 patients by the year 2020, according to a statement issued at the J.P. Morgan Healthcare Conference in San Francisco. Participating drugmakers include Amgen Inc. (Nasdaq:AMGN), Celgene Corp. (Nasdaq:CELG), GlaxoSmithKline PLC (NYSE:GSK) and NantWorks LLC, as well as health insurer Independence Blue Cross and Bank of America Corp., which is self-insured, according to the statement.
Biden meeting
Members of the coalition met with U.S. Vice President Joseph Biden, who said in a November speech that a “moonshot” was needed to cure cancer. Biden’s speech came after meeting with Soon-Shiong, the billionaire said. The coalition hasn’t asked the Obama administration for financial support, according to NantWorks.
