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Robot millionaire takes a shot at fixing severed spines

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(Bloomberg) — On a cloudy Wednesday morning in the Tokyo suburb of Tsukuba, Yoshiyuki Sankai points excitedly to a slide of severed spinal cords. They belong to rats, and he’s used cell technology to help reconnect the nerves.

A multi-millionaire whose robot company, Cyberdyne Inc., went public last year, Sankai is researching ways to repair damaged body tissue. The 57-year-old scientist’s vision: to treat patients with spinal injuries by using stem-cell related technology to repair nerve connections and robotic suits that aid movement.

His plans are getting a boost from new policies promoted by Prime Minister Shinzo Abe, who led a liberalization of approval rules to make Japan one of the world’s quickest places to get a regenerative therapy on the market. Now, Japanese corporations spanning the pharmaceutical and industrial sectors have regenerative medicine on their agenda, and industry groups estimate the domestic market for these therapies could top $25 billion by 2050.

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Investors are putting money into research that explores the potential of cells to repair damaged organs and tissues, or reverse degenerative diseases like Alzheimer’s. While scientists globally have worked for years in this field, treatments have been slow to come to market. But there’s a hope in Japan that without the political red tape, promising therapies will emerge faster and there will be speedier payouts.

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“It’s a game changer, and we expect investment to keep pouring in to Japan,” said Sanjeev Kumar, a consultant at market research firm Frost & Sullivan. “After years of struggling with slow returns on investment, regenerative medicine companies across the world see a faster path in Japan, and they’re watching closely.”

Cell revolution

Regenerative medicine is a broad umbrella that includes treatments around stem cells and gene therapy that are intended to restore the function of damaged organs and tissues.

Sankai’s company Cyberdyne is setting its sights on better treating spinal injury patients by combining multiple approaches. It makes robot exoskeletons for physical therapy, and these bionic suits can read bio-electric signals from the patient’s muscles, helping movement in the disabled. Inspired by Isaac Asimov’s “I, Robot” as a child, Sankai says his years of mapping out the brain’s nerve network for his robots fits with the research into repairing rat spines with stem cells and proteins. His hope is to eventually use various treatments together. Cyberdyne posted revenue of 631 million yen ($5.2 million) and a loss of 915 million yen in the year ended March 31, data compiled by Bloomberg show.

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Japan’s Healios K.K. is developing a treatment for an eye disease called macular degeneration that causes vision loss. Electronics giant Hitachi Ltd. announced a joint research project in cell therapy for Parkinson’s Disease in July; while Australian developer of stem cell therapies Mesoblast Ltd. is looking at more partnership deals in Japan after the regulatory changes, its Chief Executive Officer Silviu Itescu said.

Fujifilm Holdings Corp. this year spent $278 million on a company developing stem-cell products for drug testing. It supplies derived human cells to pharmaceutical companies doing trials on new drugs, providing them with an alternative to conducting tests on animals.

Game changer

Faced with an aging population, Abe is seeking to foster technologies that could create new treatments for patients while potentially providing a boost to Japan Inc. The idea is to have new industries wean the world’s third-biggest economy away from its dependence on autos.

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Regenerative medicines in Japan can now get conditional marketing approval based on results from mid-stage, or Phase II, human trials that demonstrate safety and probable efficacy. Once lagging behind the U.S. and the E.U. on approval times, there is now an approximately three-year trajectory for approvals, according to Frost’s Kumar. That compares with seven to ten years before.


While the market potential is huge, technological challenges still need to be ironed out, said Atsushi Seki, a Tokyo-based health care analyst with Barclays PLC. Therapies that use the patient’s own cells could be tougher to monetize and researchers will also need to find ways to handle transplants that are rejected by the body, he said.

The price of such therapies has been one hurdle. Around the world, companies have also faced setbacks while pushing such treatments. In the U.S., Geron Corp., which started the first nation-approved trial of human embryonic stem cells, ended the program in 2011, citing research costs and regulatory complexities.

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With new treatments expected to come online in the next few years, Japan’s government, which has a national health care program, now needs to come up with affordable payment models. Seki said he is watching to see how the country will set reimbursements for Temcell, a Mesoblast cell therapy distributed by JCR Pharmaceuticals Co. Expected towards the end of the year, if its price is disappointing, that could discourage the entire industry from developing such treatments, Seki said.

Despite the challenges, researchers like Sankai believe the new policies set the stage for various technologies to come together and new therapies to emerge.

“The speed of development is amazing: every day it’s going faster,” Sankai said in an interview at Cyberdyne’s headquarters, surrounded by a few of his robot prototypes. “But technology is only technology. What’s important is how they’re installed to the people.”